Introducción: El objetivo de esta revisión es entregar al lector, una visión general sobre el origen, clasificación y patologías asociadas a ZIKV para comprender las eventuales implicancias en el corto y mediano plazo de esta infección.
Cuerpo de la revisión: La connotación internacional tanto en el ámbito científico como periodístico, han posicionado a la infección por virus Zika (ZIKV) y sus posibles efectos como un tema relevante en los últimos meses. Uno de los efectos más importantes, es que se ha relacionado con el aumento de casos de microcefalia en las regiones del norte de Brasil.
Diversos estudios han reportado asociaciones entre la infección por este virus y sus implicancias en los recién nacidos de madres infectadas durante su embarazo. Entre ellas, destaca además de la microcefalia, lesiones oftalmológicas, hidrops y muerte fetal. Además se han descrito otras asociaciones en adultos en el ámbito neurológico, tales como Síndrome de Guillain-Barré y meningoencefalitis.
Discusión: La Organización Mundial de la Salud (OMS) ha decretado una alerta internacional sobre el virus y ha puesto hincapié en las medidas de prevención para los viajeros a las zonas en donde se han confirmado casos, dado que aún no existe una vacuna ni tratamiento específico para combartirlo.
(1) World Health Organization. WHO statement on the first meeting of the International Health Regulations (2005) (IHR 2005) Emergency Committee on Zika virus and observed increase in neurological disorders and neonatal malformations. [Internet]. [Citado el 1 febrero 2016] Disponible en: http://www.who.int/mediacentre/news/statements/2016/1st-emergency-committee-zika/en/.
(2) Organización Panamericana de la Salud / Organización Mundial de la Salud. Actualización Epidemiológica, 3 de marzo de 2016, Washington, D.C. OPS/OMS. 2016.
(3) Ministerio de Salud [www.web.minsal.cl]. Destacados: 26 de marzo de 2016. [acceso 10 de agosto 2016]. MINSAL confirma primer caso de Virus Zika autóctono, transmitido por vía sexual en Chile. Disponible en: http://web.minsal.cl/minsal-confirma-primer-caso-de-virus-zika-autoctono-transmitido-por-via-sexual-en-chile.
(4) Hayes EB. Zika virus outside Africa. Emerg Infect Dis 2009; 15: 1347-1350.
(5) Rodriguez-Morales AJ. Zika: the new arbovirus threat for Latin America. J Infect Dev Ctries 2015; 9: 684-5.
(6) Dick GW, Kitchen SF, Haddow AJ. Zika virus. Isolations and serological specificity. Trans R Soc Trop Med Hyg 1952; 46: 509-20.
(7) Boorman J, Porterfield J. A simple technique for infection of mosquitoes with viruses.Trans R Soc Trop Med Hyg. 1956 May; 50(3): 238-42.
(8) Diagne CT, Diallo D, Faye O, Ba Y, Faye O, et al. Potential of selected Senegalese Aedes spp. mosquitoes (Diptera: Culicidae) to transmit Zika virus. BMC Infect Dis. 2015 Nov 2; 15: 492.
(9) Ioos S, Mallet HP, Goffart L, et al. Current Zika virus epidemiology and recent epidemics. Med Mal infect. 2014 Jul; 44(7): 302-307.
(10) Getachew D, Tekie H, Gebre-Michael T, et al. Breeding sites of Aedes aegypti: Potential Dengue Vectors in Dire Dawa, East Ethiopia. Interdiscip Perspect Infect Dis. 2015; 2015: 706276.
(11) Pastula DM, Smith DE, Beckhman JD, Tyler KL. Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus diseases. J. Neurovirol. 2016 Jun; 22(3): 257-60.
(12) Meaney-Delman D, Rasmussen S, Staples J, et al. Zika Virus and Pregnancy: What Obstetric Health Care Providers Need to Know. Obstet Gynecol 2016; 0: 1–7.
(13) Zanluca C, Melo VC, Mosimann AL, Santos GI, Santos CN, Luz K. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz. 2015 Jun; 110(4): 569-72
(14) Cunha MS, Esposito DL, Rocco IM, Maeda AY, Vasami FG, Nogueira JS et al. First Complete Genome Sequence of Zika Virus (Flaviviridae, Flavivirus) from an Autochthonous Transmission in Brazil. Genome Announc. 2016. 3; 4(2).
(15) Duffy MR, Chen TH, Hancock WT, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009 Jun 11; 360(24): 2536-43.
(16) Cao-Lormeau VM, Musso D. Emerging arboviruses in the Pacific. Lancet 2014 Nov 1; 384(9954): 1571-2.
(17) Centre D ́higiene et de salubrite publique.[http://www.hygiene-publique.gov.pf] 2013-2014. Bulletins de surveillance sanitaire en polynésie française et documents associés. [acceso 11 de abril 2016]. Disponible en: http://www.hygiene-publique.gov.pf/spip.php?article120.
(18) Tognarelli J, Ulloa S, Villagra E, et al. A report on the outbreak of zika virus on Easter Island, South Pacific, 2014. Arch Virol. 2016 Mar; 161(3): 665-8.
(19) Scassi F. Entry routes for Zika virus in Brazil after 2014 world cup: New possibilities. Travel Medicine and Infectious Disease. 2016; 14, 49-51.
(20) Nishiura H, Kinoshita R, Mizumoto K, et al. Short Communication: Transmission potential of Zika virus infection in the South Pacific. Intern J Infect Dis. 2016; 45: 95-97.
(21) Musso D, Nilles EJ, Cao-Lormeau VM. Rapid spread of emerging Zika virus in the Pacific area. Clin Microbiol Infect 2014; 20: 595–6.
(22) Marchette NJ, Garcia R, Rudnick A. Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia. Am J Trop Med Hyg 1969; 18: 411-5.
(23) Petersen EE, Staples JE, Meaney-Delman D, et al. Interim Guidelines for Pregnant Women During a Zika Virus Outbreak—United States, 2016. MMWR Morb Mortal Wkly Rep. 2016 Jan 22; 65(2): 30-3.
(24) Pan American Health Organization [www.paho.org]. Epidemiological alert. 1 December 2015. Neurological syndrome, congenital malformations, and Zika virus infection. Implications for public health in the Americas. [Acceso 10 de marzo 2016]. Disponible en: www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=32405&lang=en.
(25) Ginier M, Neumayr A, Günther S, Schmidt- Chanasit J, Blum J. Zika without symptoms in returning travellers: What are the implications?. Travel Med Infect Dis. 2016 Jan-Feb; 14(1): 16-2.
(26) Weitzel T. Cortes C. Zika Virus Infection in Presenting with Postauricular Lymphadenopathy. Am J. Trop Med Hyg. 2016; 95(2): 255-256.
(27) Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, et al. Genetic and Serologic Properties of Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis. 2008 Aug; 14(8): 1232-9.
(28) Staples JE, Dziuban EJ, Fischer M, Cragan JD, Rasmussen SA, Cannon MJ et al. Interim Guidelines for the Evaluation and Testing of Infants with Possible Congenital Zika Virus Infection United States, 2016. MMWR Morb Mortal Wkly Rep. 2016 Jan 29; 65(3): 63-7.
(29) Besnard M, Lastere S, Teissier A, Cao-Lormeau V, Musso D. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. Euro Surveill 2014; 19(13): 20751.
(30) Foy BD, Kobylinski KC, Chilson Foy JL, et al. Probable non–vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis. 2011 May; 17(5): 880-2.
(31) Hills SL, Russell K, Hennessey M, Williams C, Oster AM, Fischer M, et al. Transmission of Zika Virus Through Sexual Contact with Travelers to Areas of Ongoing Transmission — Continental United States, 2016. MMWR Morb Mortal Wkly Rep. 2016 Mar 4; 65(8): 215-6.
(32) Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau V-M. Potential sexual transmission of Zika virus. Emerg Infec Dis. 2015 Feb; 21(2): 359-61.
(33) Ministério da Saúde. [www.saude.gov.br]. 2015. Protocolo de atenção à saúde e resposta à ocorrência de microcefalia relacionada à infecção pelo vírus Zika Ministério da Saúde, Secretaria de Atenção à Saúde – Brasília. [acceso 15 marzo 2016]. Disponible en: www.saude.gov.br/svs.
(34) Campos GS, Bandeira AC, Sardi SI. Zika virus outbreak, Bahia, Brazil. Emerg Infect Dis 2015; 21: 1885–86.
(35) Centro de operações de emergências em saúde pública sobre microcefalias. [www.combateaedes.saude.gov.br] Informe epidemiológico no 15 semana epidemiológica 08/2016 (21 a 27/02/2016) - Monitoramento dos casos de microcefalia no brasil. [acceso 15 abril 2016]. Disponible en: http://combateaedes.saude.gov.br/images/pdf/informe_microcefalia_epidemiologico15.pdf
(36) Woods CG, Parker A. Investigating microcephaly. Arch Dis Child. 2013 Sep; 98(9): 707-13.
(37) Meaney-Delman D, Rasmussen S, Staples J, Oduyebo T, Ellington S, Petersen E, et al. Zika Virus and Pregnancy: What Obstetric Health Care Providers Need to Know. Obstet Gynecol. 2016 Apr; 127(4): 642-8.
(38) Brasil P, Pereira JP Jr, Raja Gabaglia C, Damasceno L, Wakimoto M, Ribeiro Nogueira RM et al. Zika Virus Infection in Pregnant Women in Rio de Janeiro Preliminary Report. N Engl J Med. 2016 Mar 4. DOI: 10.1056/NEJMoa1602412.
(39) Marrs C, Olson G, Saade G, Hankins G, Wen T, Patel J, et al. Zika Virus and Pregnancy: A Review of the Literature and Clinical Considerations. Am J Perinatol. 2016 Jun; 33(7): 625-39.
(40) Mlakar J, Korva M, Tul N, Popović M, Poljšak- Prijatelj M, Mraz J et al. Zika Virus Associated with Microcephaly. N Engl J Med. 2016 Mar 10; 374(10): 951-8.
(41) Martines RB, Bhatnagar J, Keating MK, Silva- Flannery L, Muehlenbachs A, Gary J et al. Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses — Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016 Feb 19; 65(6): 159-60.
(42) Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y et al. Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell. 2016 May 5; 18(5): 587-90.
(43) de Paula Freitas B, de Oliveira Dias JR, Prazeres J, Sacramento GA, Ko AI, Maia M, et al. Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil. JAMA Ophthalmol. 2016; 134(5): 529-535.
(44) Sarno M, Sacramento GA, Khouri R, et al. Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. PLoS Negl Trop Dis. 2016 Feb 25; 10(2): e0004517.
(45) World Health Organization [www.who.int.es]. Zika situation report. 19 February 2016. Zika virus microcephaly and Guillain Barré Syndrome. [acceso 20 marzo 2016]. Disponible en: http://apps.who.int/iris/bitstream/10665/204454/1/zikasitrep_19Feb2016_eng.pdf
(46) Broutet N, Krauer F, Riesen M, Khalakdina A, Almiron M, Aldighieri S, et al. Zika Virus as a Cause of Neurologic Disorders. N Engl J Med. 2016 Apr 21; 374(16): 1506-9.
(47) Cao-Lormeau VM, Blake A, Mons S, Lastère S, Roche C, Vanhomwegen J et al. Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet. 2016 Apr 9; 387(10027): 1531-9.
(48) Calvet GA, Filippis AM, Mendonça MC, Sequeira PC, Siqueira AM, Veloso VG et al. First detection of autochthonous Zika virus transmission in a HIV-infected patient in Rio de Janeiro, Brazil. J Clin Virol. 2016 Jan; 74: 1-3.
(49) Organización Mundial de la Salud. [www.who.int] Centro de Prensa. Nota descriptiva. Febrero 2016. Enfermedad por el virus Zika. [acceso 10 marzo 2016]. Disponible en: http://www.who.int/mediacentre/factsheets/zika/es/.
(50) Ahmad SS, Amin TN, Ustianowski A. Zika virus: Management of infection and risk. BMJ 2016 Feb 26; 352: i1062.